METHODS OF DIAGNOSING AND TREATING CANCER IN PATIENTS HAVING OR DEVELOPING RESISTANCE TO A FIRST CANCER THERAPY
摘要
A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided.
申请公布号
WO2011112678(A1)
申请公布日期
2011.09.15
申请号
WO2011US27689
申请日期
2011.03.09
申请人
DANA-FARBER CANCER INSTITUTE, INC.;THE BROAD INSTITUTE, INC.;GARRAWAY, LEVI, A.;JOHANNESSEN, CORY, M.