发明名称 |
SCHWANN CELLS ORIGINATING FROM BONE MARROW STROMAL CELLS |
摘要 |
<p>There is provided a method of inducing bone marrow stromal cells to differentiate into bone marrow stromal cell-derived Schwann cells in Vitro, comprising the steps of: collecting bone marrow stromal cells from bone marrow and culturing the cells in a standard essential culture medium supplemented with a serum; adding a reducing agent to the culture medium and further culturing the cells; adding a differentiation inducing agent to the culture medium and further culturing the cells; and adding a cyclic AMP-augmenting agent or a cyclic AMP analogue and/or a glial cell differentiation and survival stimulating factor to the culture medium, and further culturing the cells to obtain the bone marrow stromal cell-derived Schwann cells. There are also provided bone marrow stromal cell-derived Schwann cells obtained thereby and a pharmaceutical composition for neural regeneration that comprises them.</p> |
申请公布号 |
EP1405906(B1) |
申请公布日期 |
2011.09.14 |
申请号 |
EP20020738782 |
申请日期 |
2002.06.21 |
申请人 |
SANBIO, INC. |
发明人 |
DEZAWA, MARI;SAWADA, HAJIME;TAKANO, MASAHIKO |
分类号 |
C12N5/079;A61K35/00;A61K35/12;A61L27/00;A61L27/38;A61P25/00;A61P43/00;C12N5/18 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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