发明名称 |
NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION |
摘要 |
<p>The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.</p> |
申请公布号 |
EP2364309(A2) |
申请公布日期 |
2011.09.14 |
申请号 |
EP20090832541 |
申请日期 |
2009.12.10 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
PHADKE, AVINASH;CHEN, DAWEI;GADHACHANDA, VENKAT;HASHIMOTO, AKIHIRO;PAIS, GODWIN;WANG, XIANGZHU;AGARWAL, ATUL;KIM, HA YOUNG;LI, SHOUMING;LIU, CUIXIAN;ZHANG, SUOMING;DESHPANDE, MILIND |
分类号 |
C07D403/14;A61K38/05;A61P31/12;C07D403/12;C07D417/14;C07K5/06 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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