发明名称 |
Method for inhibiting the expression of a target gene and medicine for treating a tumour illness |
摘要 |
<p>Method for inhibiting expression of a target gene (A) in a cell by introducing at least one oligoribonucleotide (O1) that has a double-stranded (ds) structure consisting of at most 49 sequential nucleotide (nt) pairs, with at least part of one strand (S1) complementary with (A), and has, at least one end, a single-stranded (ss) segment of 1-4 nt. Independent claims are also included for: (a) O1 that target any of 140 gene sequences defined in the specification; and (b) kit comprising at least one O1, at least one other oligoribonucleotide (O2) with same size and structure as O1 but not necessarily having an ss-end, and/or interferon. ACTIVITY : Cytostatic; virucide; protozoacide; antibacterial. No biological data given. MECHANISM OF ACTION : Antisense inhibition of gene expression. No biological data given.</p> |
申请公布号 |
EP2365075(A1) |
申请公布日期 |
2011.09.14 |
申请号 |
EP20100011812 |
申请日期 |
2002.01.09 |
申请人 |
ALNYLAM EUROPE AG |
发明人 |
KREUTZER, ROLAND;LIMMER, STEFAN;VORNLOCHER, HANS-PETER;HADWIGNER, PHILIPP;GEICK, ANKE;OCKER, MATTHIAS;HEROLD, CHRISTOPH;SCHUPPAN, DETLEF |
分类号 |
C12N15/09;A61K31/7105;A61K31/7115;A61K31/713;A61K48/00;A61P1/18;A61P35/00;C12N15/113;C12N15/88 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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