A biopsy system comprising a housing, a biopsy instrument being operatively associated with the housing and including a first tubular member having a tissue basket formed near a distal end thereof, the tissue basket being configured for retrieval of tissue, the biopsy instrument further including a tubular knife member coaxially disposed relative to the first tubular member and being configured for cooperative movement with the first tubular member to sever a tissue sample from a patient; and an indexing assembly operatively engageable with the biopsy instrument for selective orientation of the tissue basket.