发明名称 |
Compositions and methods to treat cancer with cupredoxins and CpG rich DNA |
摘要 |
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
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申请公布号 |
US8017749(B2) |
申请公布日期 |
2011.09.13 |
申请号 |
US20070950165 |
申请日期 |
2007.12.04 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
DAS GUPTA TAPAS;CHAKRABARTY ANANDA |
分类号 |
A61K39/00;A01N37/18;A61K39/02;A61K39/108;A61K39/38;A61K48/00;A61P31/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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