| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel antitumour compounds of general formula I ^ , where R1-16 are groups independently selected from hydrogen, protected or unprotected hydroxyl, C1-C24 alkyl, C2-C24 alkenyl, =O and ORa, OCORa; X and Y are C5-C12 alkyl groups which are substituted with one or more C1-C6 alkyl groups, hydroxyl groups and/or tetrahydropyran which can be optionally substituted with an alkyl and/or ORa group; Ra is independently selected from hydrogen and C1-C12 alkyl; and the dotted line denotes a double bond. The invention also relates to a method of producing said compounds, a pharmaceutical composition based on said compounds, having antitumour activity and use of formula I compounds to prepare a medicinal agent for treating cancer. ^ EFFECT: novel compounds which have cytotoxic activity and can be used to treat cancer are obtained and described. ^ 15 cl, 2 ex, 2 tbl |
