VACCINES AND VACCINE COMPOSITIONS, AND METHODS FOR THE MANUFACTURE THEREOF

摘要

A vaccine including inactivated influenza A viruses that include or carry H5 hemagglutinin and at least one neuraminidase of a subtype selected from a group including Nl, N2, N5, N6, N7, and N8 neuraminidase. The H5 hemagglutinin can be derived from A/chicken/Thailand/704/77. The Nl neuraminidase can be derived from type A/Puerto Rico/9/1934, the N2 neuraminidase can be derived from A/Singapore/1/57, the N5 neuraminidase can be derived from type A/Duck/ Alberta/60/1976, the N6 neuraminidase can be derived from A/gull/Maryland/704/77, the N7 neuraminidase can be derived from A/chicken/Germany/N/49, and the N8 neuraminidase can be derived from A/duck/Australia/341/83.