发明名称 |
Compositions and methods for inhibiting expression of the HAMP gene |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition. |
申请公布号 |
AU2007299629(B2) |
申请公布日期 |
2011.09.08 |
申请号 |
AU20070299629 |
申请日期 |
2007.09.21 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
TAN, PAMELA;GEICK, ANKE;LIN, HERBERT Y.;NAKAYAMA, TOMOKO |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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