发明名称 |
MONOCLONAL ANTIBODIES AGAINST HMGB1 |
摘要 |
In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
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申请公布号 |
US2011217292(A1) |
申请公布日期 |
2011.09.08 |
申请号 |
US20100897453 |
申请日期 |
2010.10.04 |
申请人 |
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发明人 |
NEWMAN WALTER;QIN SHIXIN;O'KEEFE THERESA L.;OBAR ROBERT A. |
分类号 |
A61K39/395;A61P1/00;A61P11/00;A61P11/06;A61P31/00;A61P37/02;C07K14/47;C07K16/00;C07K16/18;C12N5/10;C12N5/20;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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