Use of lipid conjugates in the treatment of disease

摘要

Abstract Use of a compound represented by the structure of the general formula (A): L-Z-Y--X - - n 5 (A) wherein L is a lipid or a phospholipid; Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol; Y is either nothing or a spacer group ranging in length from 2 to 30 atoms; 10 X is a physiologically acceptable monomer, dimer, oligomer, or polymer; and n is a number from I to 1000 for the preparation of a composition to treat asthma. 2783a971 (GHMatters) P75827.AU.1 Fig. 1.1: Inhibition of endothelin-1 (ET)-induced contraction of rat tracheal rings by Lipid-conjugates. A: Contraction of rat trachea by Endothelin-1. -9 -8 -7 -6 -5 -4 Log[ET] B: Effect of HYPE on ET induced contraction of rat 100 trachea. 0, 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 HYPE [M]