发明名称 |
COMPOUNDS FOR STIMULATING P-GLYCOPROTEIN FUNCTION AND USES THEREOF |
摘要 |
The present invention is directed to polypeptides (e.g., fragments) derived from P-glycoprotein and caveolin-1 which are capable of inhibiting the interaction between these two proteins. Inhibition of this interaction leads to increase of efflux of compounds that are transported by P-gp. The invention further includes methods of treating patients having diseases that benefit from increased P-gp-mediated efflux. Such diseases include neoplasms such as cancer and neurological diseases such as neurodegenerative diseases.
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申请公布号 |
US2011218152(A1) |
申请公布日期 |
2011.09.08 |
申请号 |
US20070446434 |
申请日期 |
2007.10.19 |
申请人 |
BELIVEAU RICHARD;DEMEULE MICHEL;BARAKAT STEPHANE;MICHAUD-LEVESQUE JONATHAN |
发明人 |
BELIVEAU RICHARD;DEMEULE MICHEL;BARAKAT STEPHANE;MICHAUD-LEVESQUE JONATHAN |
分类号 |
A61K38/16;A61K38/03;C07K7/06;C07K7/08;C07K14/00;C12N5/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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