发明名称 |
STABILIZED APTAMERS TO PLATELET DERIVED GROWTH FACTOR AND THEIR USE AS ONCOLOGY THERAPEUTICS |
摘要 |
Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto. |
申请公布号 |
EP1807107(B1) |
申请公布日期 |
2011.09.07 |
申请号 |
EP20050824135 |
申请日期 |
2005.11.02 |
申请人 |
ARCHEMIX CORP. |
发明人 |
PREISS, JEFFREY;WILSON, CHARLES;STANTON, MARTIN;DIENER, JOHN;EPSTEIN, DAVID;MCCAULEY, DILARA;MCCAULEY, THOMAS |
分类号 |
A61K38/17;A61K31/337;A61K31/427;A61K31/4745;A61K31/522;A61K31/704;A61K31/7048;A61K31/7072;C07K14/715;C12N15/11;C12N15/115 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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