<p>An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent.; In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.</p>
申请公布号
EP2363112(A2)
申请公布日期
2011.09.07
申请号
EP20110165433
申请日期
2007.08.08
申请人
INTARCIA THERAPEUTICS, INC
发明人
ALESSI, THOMAS, R.;DESJARDIN, MICHAEL, A.;LAM, STAN;LAUTENBACK, SCOTT, D.;ZAMORA, PAULINE, C.