发明名称 |
ISOINDOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS. |
摘要 |
<p>Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.</p> |
申请公布号 |
MX2011006084(A) |
申请公布日期 |
2011.09.06 |
申请号 |
MX20110006084 |
申请日期 |
2009.12.08 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC. |
发明人 |
NG, PUI YEE;VU, CHI B.;MCPHERSON, LAUREN;BLUM, CHARLES |
分类号 |
C07D403/12;A61K31/4035;A61K31/427;A61K31/437;A61K31/443;A61K31/4439;A61K31/4523;A61K31/498;A61K31/4985;A61K31/519;A61K31/5377;A61P1/00;A61P3/04;A61P3/06;A61P3/10;A61P5/14;A61P5/38;A61P5/50;A61P7/02;A61P7/06;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P19/02;A61P21/00;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P27/04;A61P27/06;A61P27/12;A61P31/12;A61P31/16;A61P31/22;A61P35/00;A61P35/02;A61P37/00;A61P37/06;A61P43/00;C07C201/12;C07C205/57;C07C205/58;C07D209/46;C07D213/61;C07D401/12;C07D401/14;C07D405/12;C07D417/12;C07D471/04;C07D487/04 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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