发明名称 Use of the cathelicidin LL-37 and derivatives therof for wound healing
摘要 Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
申请公布号 US8012933(B2) 申请公布日期 2011.09.06
申请号 US20080232215 申请日期 2008.09.12
申请人 LIPOPEPTIDE AB 发明人 STAAHLE-BAECKDAHL MONA;HEILBORN JOHAN;CARLSSON ANDERS;BOGENTOFT CONNY
分类号 A61K38/16;A61K;A61K9/127;A61K38/00;A61P17/02;A61P35/00;C07K14/00;C07K14/47;C12N5/00;C12N5/071;C12N15/09 主分类号 A61K38/16
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