发明名称 |
Anti-clogging device and method for in-gel digestion applications |
摘要 |
An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum. The device also reduces or eliminates overflowing of a well in the event a drain becomes clogged during automated operation.
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申请公布号 |
US8012434(B2) |
申请公布日期 |
2011.09.06 |
申请号 |
US20080288658 |
申请日期 |
2008.10.22 |
申请人 |
MILLIPORE CORPORATION |
发明人 |
CLARK PHILLIP;SCOTT CHRIS A.;EMERICK MARC;KOPACIEWICZ WILLIAM;RISING DONALD B. |
分类号 |
B01L3/00;G01N33/48;B01J20/28;G01N1/28;G01N1/40;G01N27/447;G01N30/00;G01N33/68 |
主分类号 |
B01L3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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