发明名称 |
Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage |
摘要 |
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroacetate. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or neuronal cell death caused by in embodiments, toxicity or hypoxia. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.
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申请公布号 |
US8013170(B2) |
申请公布日期 |
2011.09.06 |
申请号 |
US20070002178 |
申请日期 |
2007.12.14 |
申请人 |
HARRIS PAUL WILLIAM RICHARD;BRIMBLE MARGARET ANNE |
发明人 |
HARRIS PAUL WILLIAM RICHARD;BRIMBLE MARGARET ANNE |
分类号 |
C07D487/02;A61K;A61K31/395;A61P25/16;A61P25/28;C07D225/00;C07D245/04;C07D471/04;C07D487/04;C07D491/02;C07D495/02;C07D497/02 |
主分类号 |
C07D487/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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