| 摘要 |
PROBLEM TO BE SOLVED: To provide a therapeutic agent for arrhythmia, i.e. to provide a novel tricyclic chroman compound that has an IKACh inhibitor activity and is useful for treating and/or preventing arrhythmia. SOLUTION: A benzopyran derivative represented by formula (I) (wherein R<SP>1</SP>and R<SP>2</SP>are each 1C-6C alkyl group or the like; R<SP>3</SP>is hydroxyl group or the like; R<SP>4</SP>is hydrogen atom or the like; X is 1C-6C alkylene group or the like; R<SP>5</SP>is hydrogen atom or the like; R<SP>6</SP>is 1C-6C alkyl group, 3C-8C cycloalkyl group, 3C-8C cycloalkenyl group, 6C-14C aryl group, 2C-9C heteroaryl group, 2C-9C heterocyclyl group or the like; V is a substituent chosen from substituent group V<SP>1</SP>; m is an integer of 0-2; and A is a 5-, 6- or 7-membered ring that fuses with a benzene ring by sharing two carbon atoms) or a pharmaceutically acceptable salt thereof is provided. COPYRIGHT: (C)2011,JPO&INPIT
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