The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
申请公布号
CA2788600(A1)
申请公布日期
2011.09.01
申请号
CA20112788600
申请日期
2011.02.18
申请人
ARROWHEAD RESEARCH CORPORATION
发明人
HADWIGER, PHILIPP;HOFFMANN, TORSTEN;KITAS, ERIC A.;LEWIS, DAVID L.;MOHR, PETER;ROZEMA, DAVID B.;THUER, WILMA;VALIS, LINDA CHRISTINE;WAKEFIELD, DARREN H.
