发明名称 PLATELET ADP RECEPTOR INHIBITORS
摘要 Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.
申请公布号 US2011212983(A1) 申请公布日期 2011.09.01
申请号 US20090642379 申请日期 2009.12.18
申请人 PORTOLA PHARMACEUTICALS, INC. 发明人 SCARBOROUGH ROBERT M.;JANTZEN HANS-MICHAEL;HUANG WOLIN;SEDLOCK DAVID M.;MARLOWE CHARLES
分类号 A61K31/506;C07D239/48;A61K31/381;A61K31/4035;A61K31/427;A61K31/4365;A61K31/443;A61K31/4436;A61K31/4439;A61K31/497;A61K31/501;A61P7/02;A61P9/00;A61P9/04;A61P9/10;A61P43/00;C07D239/22;C07D239/50;C07D333/34;C07D401/04;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/12;C07D409/14;C07D417/12;C07D495/04 主分类号 A61K31/506
代理机构 代理人
主权项
地址