发明名称 CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS
摘要 The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.
申请公布号 US2011212028(A1) 申请公布日期 2011.09.01
申请号 US200913119398 申请日期 2009.09.16
申请人 发明人 AHMED KARIEM;EL ANDALOUSSI SAMIR;GUTRESTAM PETER;HALLBRINK MATTIAS;JOHANSSON HENRIK;LANGEL ULO;LEHTO TAAVI;LINDGREN MARIA;MAGER IMRE;SILLARD RANNAR;ROSENTHAL AIZMAN KATRI;TEDEBARK ULF;LUNDIN PER
分类号 A61K49/00;A61K47/42;A61P31/04;A61P35/00;C07K2/00;C07K7/06;C07K7/08;C07K9/00;C07K14/00;C12N5/00;C12N15/63 主分类号 A61K49/00
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