发明名称 |
USE OF ENDOGENOUS ANTIOXIDANT PROTEINS IN THE TREATMENT OF STROKE |
摘要 |
Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Infusion of human umbilical cord blood (HUCB) cells protects striatal white matter tracts in vivo and directly protects mature primary OL cultures from oxygen glucose deprivation (OGD). Microarray studies of RNA prepared from OL cultures subjected to OGD and treated with HUCB cells showed an increase in the expression of 33 genes associated with OL proliferation, survival, and repair functions, such as myelination. Immunohistochemistry showed antioxidant protein expression was upregluated in the ipsilateral white matter tracts of rats infused with HUCB cells 48 hrs after middle cerebral artery occlusion (MCAO). These results show expression of genes induced by HUCB cell therapy that could confer oligoprotection from ischemia. |
申请公布号 |
WO2011106674(A2) |
申请公布日期 |
2011.09.01 |
申请号 |
WO2011US26284 |
申请日期 |
2011.02.25 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;PENNYPACKER, KEITH RONALD;WILLING, ALISON ELIZABETH |
发明人 |
PENNYPACKER, KEITH RONALD;WILLING, ALISON ELIZABETH |
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