| 摘要 |
A surface treatment process for improving the wettability of at least part of an implantable medical device comprises the application of a non-ionic substance having at least one polar covalently-bonded group to the surface of the implantable medical device to form a stable deposition of the substance on the surface of the device. Preferably the substance is a carbohydrate, such as a sugar or sugar alcohol. The sugar may be a monosaccharide or a disaccharide, such as fructose, maltose, dextrose, glucose, sucrose or a combination thereof. The sugar alcohol can be xylitol. The non-ionic substance may be applied to the surface of the implantable device in solution, such as an aqueous solution, followed by drying of the device. The implantable device can be composed of metal, e.g. titanium, and may be a dental implant. A biomolecule can be applied to the substance on the surface of the implantable device. In another aspect, an implantable medical device with a surface coating of a non-ionic substance having at least one polar covalently-bonded group is claimed. |
