METHOD FOR PRODUCING COMPREHENSIVE ANTI-SURFACE ANTIBODY WHEREIN THE ANTIGEN USED IS A MICROORGANISM FIXED BY A PROTEIN CROSSLINKING AND FIXATION REAGENT

摘要

A method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism and the comprehensive antibodies obtained by the method are provided. The method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism comprises:
(a) treating a microorganism with a protein crosslinking and immobilization reagent and thus immobilizing proteins expressed on the surface of the microorganism via intramolecular crosslinking;
(b) administering the microorganism as an immunogen immobilized using the protein crosslinking and immobilization reagent to an animal; and
(c) obtaining antibodies from the animal.