发明名称 |
Truncated fragments of alpha-synuclein in Lewy body disease |
摘要 |
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in trycine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue (117) and before residue (126) of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals. |
申请公布号 |
EP2361928(A1) |
申请公布日期 |
2011.08.31 |
申请号 |
EP20100189868 |
申请日期 |
2004.05.19 |
申请人 |
ELAN PHARMACEUTICALS INC.;FLINDERS UNIVERSITY |
发明人 |
CHILCOTE, TAMIE J.;GOLDSTEIN, JASON;GAI, WEI PING;ANDERSON, JOHN P. |
分类号 |
C07K14/47;A01K67/00;A01K67/027;A01K67/033;A01N43/04;A61K;A61K31/70;A61K39/395;C07K1/00;C07K14/00;C07K17/00;C12N15/10;C12Q1/68;G01N33/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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