发明名称 IL-1 BINDING PROTEINS
摘要 <p>The present invention encompasses IL-1αbinding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1αand neutralize IL-1αactivity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1αand for inhibiting IL-1αactivity, e.g., in a human subject suffering from a disorder in which IL-1αactivity is detrimental.</p>
申请公布号 SG172855(A1) 申请公布日期 2011.08.29
申请号 SG20110049012 申请日期 2010.01.29
申请人 ABBOTT LABORATORIES 发明人 HSIEH, CHUNG-MING;WU, CHENGBIN
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