发明名称 |
MALATE SALT OF N- (4- { [ 6, 7-BIS (METHYLOXY) QUIN0LIN-4-YL] OXY}PHENYL)-N' - (4 -FLUOROPHENYL) CYCLOPROPANE-1,1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEROF FOR THE TREATMENT OF CANCER |
摘要 |
Disclosed are malate salts of N-(4-{ [6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)- N'-(4-fluorophenyl)cyclopropane-l,l-dicarboxamide, including a (L)-malate salt, a (D)- malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)- cyclopropane-l,l-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4- ffuorophenyl)cyclopropane- 1, 1 -dicarboxamide. |
申请公布号 |
SG173014(A1) |
申请公布日期 |
2011.08.29 |
申请号 |
SG20110051422 |
申请日期 |
2010.01.15 |
申请人 |
EXELIXIS, INC.;BRISTOL-MEYERS SQUIBB COMPANY |
发明人 |
BROWN, ADRIAN, ST. CLAIR;LAMB, PETER;GALLAGHER, WILLIAM, P. |
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