FC GAMMAD RIIB - SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF

摘要

The present invention relates to antibodies or fragments thereof that specifically bind FcyRIIB, particularly human FcyRIIB, with greater affinity than said antibodies or fragments thereof FcyRIIA, particularly human FcyRIIA. The present invention also provides the use of an anti-FcyRI1B antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention..Figure Nos. 1A and 1B