发明名称 |
NOVEL POLYMORPHIC FORMS OF 3-(1-{3-[5-(1-METHYL-PIPERIDIN-4YLMETHOXY)-PYRIMIDIN-2-YL]-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZIN-3-YL)-BENZONITRILE HYDROCHLORIDE SALT AND PROCESSES OF MANUFACTURING THEREOF |
摘要 |
<p>The present invention relates to hydrochloride solvates of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.</p> |
申请公布号 |
SG172831(A1) |
申请公布日期 |
2011.08.29 |
申请号 |
SG20110048576 |
申请日期 |
2009.12.04 |
申请人 |
MERCK PATENT GMBH |
发明人 |
BECKER, AXEL;KUEHN, CLEMENS;SAAL, CHRISTOPH;SCHADT, OLIVER;DORSCH, DIETER;BOKEL, HEINZ-HERMANN;STIEBER, FRANK;DONINI, CHRISTINA |
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