XAF-1, a diagnostic marker for interferon responsiveness in multiple sclerosis

摘要

Provided is a method of determining interferon responsiveness in a patient suffering from quiescent secondary progressive multiple sclerosis and/or active secondary progressive multiple sclerosis, the method comprising: 5 (a) determining an amount of a XAF-I gene expression level in a blood sample obtained from the patient, the patient being treated with the interferon; and (b) correlating the amount of the XAF-1 gene expression level in the blood sample with the responsiveness of the patient to the interferon.