Cell-surface decoration with active agents

摘要

Provided is a lipid vesicle, comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent, wherein the ligand portion is selected from the group consisting of a streptavidin, avidin, poly-histidine, a cysteine thiol group, a peptide C-terminal carboxyl group, and a peptide N-terminal amino group; a phospholipid that is a stable vesicle former; and an unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid that is not a stable vesicle former, a PEG, a raft former, and a fusion protein. The functionalized lipid can comprise a phospholipid or 1,2-dioleoyl-sn-glycero-3- { [N(5-amino-1-carboxypentyl)iminodiacetic acid]succinyl} . The compositions can be used to inhibit rejection of transplanted tissues or organs or ischemia-reperfusion injury.