SELECTIVE TR-BETA 1 AGONIST

摘要

A compound of formula (I) including its tautomers and pharmaceutically acceptable salts, wherein, R = OR1, NHR1. wherein further R1 is selected from H, unsubstituted or substituted groups selected from (C1-C6)alkyl, ar(C1-C6)alkyl groups; R2 represents hydrogen, hydroxyl, halo, unsubstituted or substituted groups selected from (C1-C6) alkyl, acyl (C1-C8), oxo, (C3-C7)cycloalkyl, aryl (C6-C?12), heteroaryl (C3-C12), alkoxy(C1-C6), aryloxy, aralkyl, aralkoxy, carboxylic acid and its derivatives selected from (C1-C3)alkyl esters and amides, sulfenyl derivatives, sulfonyl derivatives or the groups representing -CONR5R6, -SO2NR5R6, wherein R5 & R6 may be same or different and are independently selected from H, unsubstituted or substituted groups selected from (C1-C6)alkyl, (C3-C7)cycloalkyl, bicycloalkyl, aryl (C6-C12) or the groups R5 & R6 together with the nitrogen atom to which they are attached, form a five to eight membered cyclic ring which may contain one or more hetero atoms selected from N, S, O; R3, R4 are same or different and independently selected from H, halogen, unsubstituted or substituted (C1-C6)alkyl groups; X is selected from O, -CH2-, CO; 'n' represents the integers 0 or 1; R7 represents H, unsubstituted or substituted groups selected from (C1-C6)alkyl, aryl (C6-C12) groups; with the provision that when n =0, R7 does not represent 'H'. The compounds are useful for treating diseases caused by dyslipidemia or obesity.