| 摘要 |
Disclosed is a use of a 5-sulfonyl-phenyl-thiazole compound of formula (l): wherein: R1 is selected from alkyl, cycloalkyl, aryl and heterocyclyl; R2 is selected from alkyl and cycloalkyl; and R3 is an alkyl radical, or a pharmaceutically acceptable salt, and/or solvate thereof, in the preparation of a medicament for the treatment of polyarthritis, spondiloarthropathies, glomerulonephritis, colagenopathies, tubulo-interstitial nephritis, metabolic syndrome, atherosclerosis, osteoarthritis, asthma, chronic obstructive pulmonary disease, interstitial lung disease, multiple sclerosis, demyelinating diseases, meningitis, encephalitis, meningoencephalitis, inflammatory radiculopathies and peripheral neuropathies, inflammatory bowel disease, cirrhosis, hepatitis, heart failure, ischemic disease, renal failure, inflammatory cystitis, benign prostatic hyperplasia, prostatitis, myocarditis, pericarditis, uveitis, atopic dermatitis, eccema, urticaria, psoriasis, rosacea, allergic rhinitis, sepsis, septic shock, multiorganic failure, systemic autoimmune diseases such as systemic lupus erythematosus, vasculitis, dermatomyositis, amyloidosis or sarcoidosis, organ specific autoimmune diseases such as myasthenia gravis, or insulinitis, organ transplantation, infectious ant tumor induced inflammation, TNF-alpha dependent cellular degeneration, necrosis, apoptosis, graft versus host disease, cachexia and autocrine and paracrine pathological cell growth. Also disclosed is a compound of formula (I) when R2 - cyclopentyl, R1 is alkyl, cycloalkyl, aryl and heterocyclyl, R3 = alkyl.
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