Transmucosal delivery devices with enhanced uptake

摘要

C:/NRPonbl/DCC/RBRU3798726_ LDOC-85/2011 The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment. - 42 - Figure 1. Mean Fentanyl Concentration-Time Plots For Three Exemplary Devices of the Invention and OTFC 1.6 - -- OTFC (800 mcg fentanyl) --- Device at pH 6 (800 mcg fentanyl) _~ -e- Device at pH 7.25 (800 mcg fentanyl) 0 1.2 - +Device at pH 8.5 (800 mcg fentanyl) o 1 0 10 20 30 40 50 Time After Drug Administration (hr)