摘要 |
Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound. |
申请人 |
ADVANCED CANCER THERAPEUTICS, LLC;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;CHAND, POORAN;CHESNEY, JASON, A.;CLEM, BRIAN, F.;TAPOLSKY, GILLES, H.;TELANG, SUCHETA;TRENT, JOHN, O. |
发明人 |
CHAND, POORAN;CHESNEY, JASON, A.;CLEM, BRIAN, F.;TAPOLSKY, GILLES, H.;TELANG, SUCHETA;TRENT, JOHN, O. |