| 摘要 |
<p>The present invention relates to piperidine derivatives of formula (I) and (II), their pharmaceutical compositions and methods of treatment of metabolic syndrome disorders such as obesity, diabetes, hypertension and hyperlipidemia using the said compounds. Formula (I) Formula (II) In formula (I), X and Y represent optionally substituted aryl or heteroaryl; R1 represents H or optionally substituted lower alkyl; R2 represents H, optionally substituted lower alkyl, ester, optionally substituted alkoxycarbonyl, acyl, thioester, thioacyl, thioether, optionally substituted alkoxyl, amino, optionally substituted aminoalkyl, amido or acylamino; and R3 represents H or OH. In formula (II), X represents optionally substituted aryl or heteroaryl; R4 represents H or optionally substituted lower alkyl; and R5 represents optionally substituted lower alkyl.</p> |
