COMPOSITIONS BASED ON THE FIBRONECTIN EXTRACELLULAR DOMAIN A FOR THE TREATMENT OF MELANOMA

摘要

The invention relates to conjugates adequate for the generation of an immune response against melanoma or a metastasis thereof which comprise a melanoma antigenic polypeptide or peptide and the extracellular domain A of fibronectin. The invention relates as well to compositions comprising the conjugate of the invention and one or more adjuvants including poy(I:C), imiquimod and/or anti-CD40. The invention relates as well to methods for the treatment of melanoma or of a metastasis thereof using the conjugates or the compositions of the invention.