发明名称 AN IMPROVED PROCESS FOR PREPARING TELMISARTAN
摘要 The present invention relates to an improved process for preparing telmisartan from 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-propyl-1H-benzimidazole and 2-[4-(bromomethyl)phenyl] benzoate by using condensation reaction and hydrolysis reaction wherein the condensation reaction is performed to prepare an intermediate by using mixed solvent of dimethyl sulfoxide and isopropanol as reaction solvent using dimethyl sulfoxide of 0.5~1.5 times and isopropanol of 1.5~4.5 times on the basis of the usage of 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-prophyl-1H-benzimidazole and the hydrolysis reaction is performed to cause the reaction in mixed solvent of methanol of 7~9 times and purified water of 5~7 times on the basis of the intermediate. The process for preparing telmisartan according to the present invention provides a simple preparing process for mass production and improves a manufacturing yield with high purity by eliminating an additional process for removing an inorganic salt as a byproduct due to a base used in the condensation reaction and the hydrolysis reaction.
申请公布号 WO2011102645(A2) 申请公布日期 2011.08.25
申请号 WO2011KR01041 申请日期 2011.02.17
申请人 DONG WHA PHARM. CO., LTD.;OH, YOON-SEOK;LIM, JAE-KYUNG;CHOI, JUNG-UK;KWON, O-JIN;LEE, JUN-SANG 发明人 OH, YOON-SEOK;LIM, JAE-KYUNG;CHOI, JUNG-UK;KWON, O-JIN;LEE, JUN-SANG
分类号 C07D403/10;C07D403/04;C07D403/06 主分类号 C07D403/10
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