A POLYNUCLEOTIDE FOR USE IN TREATMENT OF INFLUENZA A VIRUS INDUCED DISEASES, ENCODING MODIFIED MX PROTEIN, SAID MODIFIED MX PROTEIN, AND A TRANSGENIC ANIMAL EXPRESSING GENE ENCODING MODIFIED MX PROTEIN

摘要

The present invention refers to a polynucleotide for use in preventive and/or therapeutic treatment of influenza A virus induced diseases in mammals, wherein the polynucleotide comprises a gene encoding for Mx protein having a TRAF2 and/or a TRAF6 binding domain. The present invention also provides a transgenic animal having decreased susceptibility for influenza A viruses, expressing a gene encoding a Mx protein, which Mx protein is having a TRAF2 and/or a TRAF6 binding domain; provided that the animal does not belong to the taxononic groups of Primates, Bovidae (Bos, Bubalus, Ovis), Pinnipedia or Rodentia.