发明名称 |
PURIFICATION METHOD FOR ADEFOVIR DIPIVOXIL |
摘要 |
The present invention relates to a novel method of purifying adefovir dipivoxil of Formula 1. The purification method according to the present invention comprises the steps of dissolving impure adefovir dipivoxil containing byproducts generated during a synthetic reaction, salts thereof or complexes thereof in water or a water-containing mixed solvent; purifying the adefovir dipivoxil solution through a reverse-phase column; and adding a base to the purified adefovir dipivoxil solution and extracting the same with an organic solvent. Further, the present invention provides a method of preparing amorphous adefovir dipivoxil by removing the solvent from the high purity solution of adefovir dipivoxil represented by formula I purified by the above method.
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申请公布号 |
US2011207928(A1) |
申请公布日期 |
2011.08.25 |
申请号 |
US200913063449 |
申请日期 |
2009.09.10 |
申请人 |
CJ CHEILJEDANG CORPORATION |
发明人 |
CHO IL HWAN;YOON MYEONG SIK;CHOI KWANG DO;LEE YONG TACK;LEE SI BEUM;BANG SEONG CHEOL;LEE MIN KYOUNG;OH DA WON |
分类号 |
C07F9/6561 |
主分类号 |
C07F9/6561 |
代理机构 |
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主权项 |
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地址 |
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