LINEAR OLIGOMERS OF GRANULOCYTE STIMULATING PROTEIN HAVING PROLONGED SURVIVAL TIME

摘要

The present invention provides structural variants – linear oligomers of recombinant ptotein, namely, granilocyte colony stimulating factor (G-CSF) having novel pharmacodynamic and pharmacokinetic characteristics such as prolonged survival (circulation) period in plasma and longer period of biological activity as compared to monomeric protein. Structural and technological pecularities enabling to obtain recombinant proteins with improved therapeutic charcteristics that may be used in biopharmacy and medicine are disclosed.@