| 摘要 |
2-(Acylamino-acylamino)-5-phenyl-1,3-thiazole derivatives (I) are new. Thiazole derivatives of formula (I) and their acid addition salts, hydrates and solvents are new. X = O or S; Y = 1-4C alkylene; R1 = 1-10C alkyl (optionally substituted (os) by cycloalkyl, phenyl (os by 1-5 of halo, alkyl, alkoxy, fluoroalkyl and fluoroalkoxy) or thienyl (os by 1-3 alkyl groups)), cycloalkyl, thienyl (os by 1-3 alkyl groups), pyridinyl or pyrimidinyl; R2 = 1-6C alkyl (os by cycloalkyl (os by one or more of alkyl, alkoxy, OH, fluoroalkyl, fluoroalkoxy or dialkylaminoalkyl), phenyl (os by one or more of halo, alkyl, alkoxy, OH, fluoroalkyl, fluoroalkoxy or dialkylminoalkyl), alkoxy, OH or dialkylaminoalkyl); phenyl or pyridinyl (both os by one or more of halo, alkyl, alkoxy, OH, fluoroalkyl, fluoroalkoxy or dialkylminoalkyl); or cycloalkyl or piperidinyl (both os by one or more of alkyl, alkoxy, OH, fluoroalkyl, fluoroalkoxy or dialkylaminoalkyl); R3 = H or 1-6C alkyl (os by cycloalkyl); R4 = H or 1-4C alkyl; R5, R5' = H, halo, OH or alkyl; or CR5R5' = CO or oxime group such as C(=NOR7); R7 = H or alkyl; n = 0-3; and R6 = H, halo, OH, alkyl, alkoxy, dialkylaminoalkyl, fluoroalkyl or fluoroalkoxy. Unless specified otherwise alkyl moieties have 1-3C and cycloalkyl moieties 3-7C. An Independent claim is also included for the preparation of (I).
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