发明名称 |
10'-FLUORINATED VINCA ALKALOIDS PROVIDE ENHANCED BIOLOGICAL ACTIVITY AGAINST MDR CANCER CELLS |
摘要 |
A 10'-fluoro-vinca alkaloid compound or its pharmaceutically acceptable salt is disclosed, as are methods of its preparation and use. A disclosed 10'-fluoro-vinca alkaloid compound has better cytotoxic potency against leukemia and cancer cell lines, and is about 8-times more cytotoxic to a multiple drug resistant cancer cell line than is a parental 10'-unsubstituted vinca alkaloid. |
申请公布号 |
WO2011103007(A2) |
申请公布日期 |
2011.08.25 |
申请号 |
WO2011US24230 |
申请日期 |
2011.02.09 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;BOGER, DALE, L. |
发明人 |
BOGER, DALE, L. |
分类号 |
C07D471/14;A61K31/437;A61P35/00;C07D471/12 |
主分类号 |
C07D471/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|