发明名称 |
Compositions for Targeted Delivery of siRNA |
摘要 |
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
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申请公布号 |
US2011207799(A1) |
申请公布日期 |
2011.08.25 |
申请号 |
US201113032029 |
申请日期 |
2011.02.22 |
申请人 |
ROCHE MADISON INC. |
发明人 |
ROZEMA DAVID B.;LEWIS DAVID L.;WAKEFIELD DARREN H.;HOFFMANN TORSTEN;KITAS ERIK;MOHR PETER;HADWIGER PHILIPP;THUER WILMA;VALIS LINDA |
分类号 |
A61K31/7105;A61K31/711;A61K31/713;A61P1/16;A61P3/00;A61P3/06;A61P3/10;A61P31/12;A61P35/00 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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