| 摘要 |
<p>A nucleic acid molecule (I) for inhibiting expression of adhesion molecules (AM) is new, where (I) has at least one of 28 sequences given in the specification. Independent claims are included for: (1) nucleic acid molecules (Ia) that, under stringent conditions, hybridize to the same nucleic acid as (I); (2) a genetic construct (GC) that contains (I) or (Ia) and can be used to transfect cells, particularly endothelial cells; (3) small interfering RNA (siRNA) comprising a pair of molecules that hybridize, at least partly to each other, and comprise sequences (SEQ ID NO: 1) and (SEQ ID NO: 2); (SEQ ID NO: 3) and (SEQ ID NO: 4) etc., to (SEQ ID NO: 27) and (SEQ ID NO: 28); (4) a device, especially a stent, that has a coating containing (I), (Ia), GC and/or siRNA; (5) a method for inhibiting expression of AM; and (6) a vascular transplantation process, including use of (I), (Ia), GC and/or siRNA. ACTIVITY : Antiarteriosclerotic; Vasotropic; Cardiant. No biological data given. MECHANISM OF ACTION : Inhibiting expression of endothelial adhesion molecules by RNA interference.</p> |
