Modulation of beta-amyloid levels by beta-secretase bace2

摘要

The present invention is based on the findings that BACE2, a homolog of ²-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A². Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A² production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.