| 摘要 |
<p>Disclosed is an antigen-adjuvant microparticle complex which comprises adjuvant microparticles and an antigen encapsulated in the adjuvant microparticles, wherein each of the adjuvant microparticles comprises an amphipathic polymer which has a poly(hydroxy acid) as a hydrophobic segment. Also disclosed is an immunogenic composition which contains particles conjugated with the complex as an active ingredient. The complex or the immunogenic composition can induce a high immune response to a small quantity of an antigen or can induce a high immune response to an antigen by a few frequencies of administration, and is therefore useful as a vaccine that is effective for the treatment and prevention of infectious diseases, cancer and others.</p> |
