发明名称 |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom |
摘要 |
The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5′-substituent and a 2′-O-substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. |
申请公布号 |
EP2358397(A2) |
申请公布日期 |
2011.08.24 |
申请号 |
EP20090744015 |
申请日期 |
2009.10.23 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
PRAKASH, THAZHA, P.;SWAYZE, ERIC, E. |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|