发明名称 |
METHODS OF MEASURING ADAMTS13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF |
摘要 |
The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. |
申请公布号 |
EP2358895(A1) |
申请公布日期 |
2011.08.24 |
申请号 |
EP20090764426 |
申请日期 |
2009.12.03 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA |
发明人 |
VARADI, KATALIN;ROTTENSTEINER, HANSPETER;TURECEK, PETER;SCHWARZ, HANS-PETER;SCHREINER, JUTTA |
分类号 |
G01N33/573;C12Q1/37;C12Q1/56;G01N33/86 |
主分类号 |
G01N33/573 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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